Neonatal & Developmental Medicine–

Child Development/Otitis Media Study

Purpose

Dev MedDevelopmental impairments in children have been attributed to persistent middle ear effusion in the first 3 years of life. This large prospective study consisted of a randomized clinical trial for children who reached a threshold of otitis media, a comparison of early Tympanostomy tube placement versus watchful waiting. An association study of children who had varying degrees of otitis media but did not meet randomization criteria was also conducted. Children were followed from birth through age 9 to 11 years old. Direct testing occurred at ages 3, 4, 6 and 9-11 years old.

We are now using this rich data set for secondary analyses. We have explored the early histories of children with ADHD and also looked for early life contributions to reading ability.


Funders

National Institute of Child Health and Human Development, the Agency for Healthcare Research and Quality, University of Pittsburgh Competitive Medical Research Fund, Research Advisory Committee and gifts from GlaxoSmithKline an Pfizer.


Participants

Health children, enrolled at 2 months of age.


Findings/presentations/publications

  1. Feldman HM, Dollaghan CA, Campbell TF, Colborn DK, Kurs-Lasky M, Janosky JE, Paradise JL. Parent-reported Language and Communication Skills at One and Two Years of Age in Relation to Otitis Media in the First Two Years of Life. Pediatrics, 1999, 104 (4), e52- e58 URL: http://www.pediatrics.org/cgi/content/full/104/4/e52
  2. Paradise JL, Feldman HM, Colborn DK, Campbell TF, Dollaghan CA, Rockette HE, Janosky JE, Kurs-Lasky M, Bernard BS. Parental Stress and Parent-Rated Child Behavior in Relation to Otitis Media in the First Three Years of Life. Pediatrics, 1999, 104:6, 1264-1273.
  3. Dollaghan CA, Campbell TF, Paradise JL, Feldman HM, Janosky JE, Pitcairn DL. Maternal Education and Measures of Early Conversational Speech and Language. Journal of Speech, Language, and Hearing Research, 1999, 42, 1432-1443.
  4. Feldman HM, Dollaghan C, Campbell T, Kurs-Lasky M, Janosky JE, Paradise JL. Measurement properties of the MacArthur Communicative Development Inventory at ages 1 and 2 years. Child Development March/April 2000, 71:2, 310-322.
  5. Paradise JL, Dollaghan CA, Campbell TF, Feldman HM, Bernard BS, Colborn DK, Rockette HE, Janosky JE, Pitcairn DL, Sabo DL, Kurs-Lasky M, Smith CG. Language, speech sound production, and cognition in 3-year-old children in relation to otitis media in their first 3 years of life. Pediatrics, 2000, 105, 1119-1130.
  6. Paradise JL, Feldman HM, Campbell TF, Dollaghan CA, Colborn DK, Bernard BS, Rockette HE, Janosky JE, Pitcairn DL, Sabo DL, Kurs-Lasky M, Smith CG. Early versus delayed tympanostomy-tube placement for persistent otitis media: Developmental outcomes at age 3 years. New England Journal of Medicine, 2001, 344, 1179-1187.
  7. Paradise JL, Feldman HM, Campbell TF, Dollaghan CA, Colborn DK, Bernard BS, Rockette HE, Janosky JE, Pitcairn DL, Sabo DL, Kus-lasky M, Smith CG. Early versus delayed insertion of tympanostomy tubes for persistent otitis media: developmental outcomes at age three years in relation to prerandomization illness patterns and hearing levels. Pediatrics Infectious Disease Journal, 2003, 22(4) 309-314.
  8. Campbell TF, Dollaghan CA, Rockette HE, Paradise JL, Feldman HM, Sabo D, Kurs-Lasky M. Risk Factors for Speech Delay in Three-Year-Old Children. Child Development, 2003, 74, 346-357.
  9. Feldman HM, Dollaghan CA, Campbell TF, Colborn DK, Janosky J, Kurs-Lasky M, Rockette HE, Dale PS, Paradise JL. Parent-reported language skills in relation to otitis media during the first three years of life. Journal of Speech, Language, & Hearing Research, 2003, 46(2), 273-287.
  10. Paradise JL, Dollaghan CA, Campbell TF, Feldman HM, Bernard BS, Colborn DK, Rockette HE, Janosky JE, Pitcairn DL, Kurs-Lasky M, Sabo DL, Smith CG. Otitis media and tympanostomy tube insertion during the first 3 years of life: Developmental outcomes at the age of 4 years. Pediatrics, 2003, 112, 265-277.
  11. Johnston LC, Feldman HM, Paradise JL, Bernard BS, Colborn K, Casselbrant M, Janosky JE. Tympanic membrane abnormalities and hearing levels at the ages of 5 and 6 years in relation to persistent otitis media and tympanostomy tube insertion in the first 3 years of life: A prospective study incorporating a randomized clinical trial. Pediatrics, 2004; 114:e58-e67. URL: http://www.pediatrics.org/cgi/content/fulll/114/1/e58
  12. Feldman HM, Dale, PS, Campbell TF, Colborn DK, Kurs-Lasky M, Rockette HE, Paradise JL. Concurrent and Predictive Validity of Parent Reports of Child Language at Ages 2 and 3 Years. Child Development, 2005, 76, 856-868.
  13. Paradise JL, Campbell TF, Dollaghan CA, Feldman HM, Bernard BS, Colborn DK, Rockette HE, Janosky JE, Pitcairn DL, Kurs-Lasky M, Sabo DL, Smith CG. Effect of early or delayed insertion of tympanostomy tubes for persistent otitis media on developmental outcomes at age 6 years. New England Journal of Medicine, 2005, 353, 576-586.
  14. Paradise JL, Feldman HM, Campbell TF, Dollaghan CA., Rockette HE, Pitcairn DL, Smith CG, Colborn DK, Bernard BS., Kurs-Lasky M, Janosky JE, Sabo DL, O’Connor RE, and Pelham WE. Early or Delayed Insertion of Tympanostomy Tubes and Developmental Outcomes at Nine to Eleven Years of Age. New England Journal of Medicine, 2007, 356(3):248-61.

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