Markus Covert
Academic Appointments
- Assistant Professor, Bioengineering
- Member, Bio-X
- Assistant Professor (By courtesy), Chemical and Systems Biology
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 725-6615
Professional Overview
Honors and Awards
- Robert Black Postdoctoral Fellow, Damon Runyon Cancer Research Foundation (2004-2006)
- Ezra Taft Benson Presidential Scholar, Brigham Young University (1991-1997)
Professional Education
| Ph.D.: | UCSD, Bioengineering/ Bioinformatics (2003) |
| M.S.: | UCSD, Bioengineering (2002) |
| B.S.: | Brigham Young University, Chemical Engineering (1997) |
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
Our focus is on building computational models of complex biological processes, and using these models to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors whose aberrant activity has been linked to oncogenesis, tumor progression, and resistance to chemotherapy.
Publications
- Single-cell and population NF-κB dynamic responses depend on lipopolysaccharide preparation. PLoS One. 2013; (1): e53222
- WholeCellKB: model organism databases for comprehensive whole-cell models. Nucleic Acids Res. 2013; (Database issue): D787-92
- A whole-cell computational model predicts phenotype from genotype. Cell. 2012; (2): 389-401
- Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting. Mol Syst Biol. 2012: 567
- Determining host metabolic limitations on viral replication via integrated modeling and experimental perturbation. PLoS Comput Biol. 2012; (10): e1002746
- Computational modeling of mammalian signaling networks. Wiley Interdiscip Rev Syst Biol Med. 2010 Mar-Apr; (2): 194-209
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