Bench to Bedside in Neonatology
The overall goal of our clinical research programs is to translate scientific knowledge into better understanding and treatment of diseases in childhood.
Dynamic in vivo measurements of the tempo of heme oxygenase 1 (HO-1) gene activation over a six-day time period in the liver of mice following in vivo transfection is shown in this movie. HO-1 is a key therapeutic target for the treatment of pathologic jaundice and has plieotrophic systemic effects with roles in immune regulation and stress response. This gene is developmentally regulated during the perinatal period. Having access to measurements of gene expression using the noninvasive assays developed in this laboratory has accelerated the study of intervention strategies for several disease states, and the understanding of physiology in the context of the living body.
Research Expertise
- General Sudden Infant Death (SIDS)
- Pulmonary Function
- Sleep
- Neonatal Infections
- Evidence-based Neonatology
- Perinatal Epidemiology and Quality Improvement
- Acute and Chronic Newborn Lung Disease
- Elastin and Alveolar Development
- Pulmonary Circulation and Lung Fluid Balance
- Using Light as a non-invasive Approach for Monitoring Functional Changes in Living Animal Models of Human Development and Disease
- Simulation and Virtual Reality Based Training
- Optical non-invasive diagnosis of brain injury
- Neurodevelopmental Outcome
- Visual Development in Infants
- Prevention of Anemia
- Retinopathy of Prematurity
- Neonatal Jaundice
- Heme Oxygenase Biology
- Developmental Gastroenterology
- Neonatal Nutrition
- Neonatal Respiratory Failure
